He takes over from Giovanni Stroppa, who left the team after guiding them to promotion from Serie B last season.
Nicola previously worked with Cagliari, where he helped the team avoid relegation to Serie B on a short-term contract.
Cremonese's management team praised Nicola's ability to develop a clear playing style and motivate his players, calling him the perfect candidate to lead the team in the challenging Serie A league.
The club's owners and management expressed their welcome to Nicola and wish him good luck in his new role.